CORDIS Project
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This project investigates the role of the protein ezrin in the formation and stability of microvilli on epithelial cells. It aims to understand how ezrin interacts with other proteins to facilitate membrane and actin remodeling.
Microvilli are tube-like membrane protrusions containing bundles of actin filaments located at the apical surface of epithelial cells. A key component of these microvilli is ezrin, a member of the Ezrin/Radixin/Moesin protein family, which provides a regulated linkage between the plasma membrane and the actin cytoskeleton.
The critical role of ezrin in microvillar morphogenesis has been demonstrated.
However, how ezrin is recruited to the apical surface of the cells and how ezrin contributes to…
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