CORDIS Project
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The MELANCHOR project investigates the role of Myosin VI in cellular processes like endosomal trafficking and melanosome biogenesis. It employs optogenetic tools and in vitro methods to study how Myosin VI interacts with different partners to regulate its mechanical functions.
Mechanical forces play crucial roles in the formation and maturation of many organelles and membrane vesicles.
Many of these forces originate in the action of cytoskeletal motors, but how these motors are activated and how their mechanical functions are regulated in the cell are poorly understood.
Rather than being “always on” machines, motors must often be specifically activated for distinct mechanical roles by partners.The MELANCHOR project seeks to uncover how Myosin VI (Myo6) promotes two ce…
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