CORDIS Project
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This project investigates the role of specific proteins in the formation of DNA double-strand breaks during meiosis, which is crucial for genetic diversity. By studying the condensation of RMM proteins, the project aims to uncover the mechanisms regulating DNA repair and chromosome structure.
Meiosis universally relies on the formation of DNA double-strand breaks (DSB) to initiate a genome-wide recombination program that promotes genetic diversity and is required to produce chromosomally-balanced haploid gametes. DSB formation is catalyzed by Spo11, which in acts in conjunction with nine essential partners in yeast, including the RMM proteins.
We previously found that RMM undergoes DNA-dependent condensation, and proposed that this organizes intracellular sub-compartments within whic…
UNIVERSITE CATHOLIQUE DE LOUVAIN
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