CORDIS Project
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This project investigates how DNA methylation influences cell differentiation during mouse development. By utilizing advanced genomic techniques and CRISPR technology, it aims to uncover the relationship between epigenetic marks and cell fate decisions, potentially enhancing the development of induced pluripotent stem…
A fundamental aspect of biology is the understanding of how cell fates are established and maintained.
Although it is widely accepted that epigenetic reprogramming is a central process of mammalian development, one of the most intriguing questions that remains unanswered is how DNA methylation marks contribute to cell differentiation and lineage commitment.
By combining, novel single cell genomics techniques, CRISPR/dCas9 technology and innovative analytical approaches, this project will uncover…
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