CORDIS Project
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This project focuses on developing a scalable method to access and activate microbial secondary metabolites, which are crucial for drug discovery. By utilizing DNA technologies and heterologous expression systems, the project aims to explore untapped biosynthetic genes in soil bacteria and other microorganisms to enhan…
The discoveries of microbial secondary metabolites (SM) led to an incalculable impact on human health and lifespan. A large share of the antibiotics, anticancers and immunosuppressants in use today originate from microorganisms.
However, discoveries of SMs of microbial origin through traditional approaches have declined in the past decades, depriving drug pipelines from a key source of bioactive molecules.
The consequences are dire, in particular in the case of antibiotics.
Encouragingly, the st…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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