CORDIS Project
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This project investigates the mechanisms of DNA replication and chromatin dynamics, focusing on how chromosomes are accurately duplicated during cell division. It employs techniques from molecular genetics and structural biology to explore the roles of histones and nucleosomes in this process, with applications in unde…
Each time a human cell divides, it must make an exact copy of its 46 chromosomes.
This requires precise duplication of ~6 billion base pairs of genomic DNA and all its associated proteins.
Mistakes in this process can lead to developmental defects and cancer.
Chromatin is packaged as nucleosomes comprising 147bp of DNA wrapped around a core of eight histone proteins.
The nucleosome is a stable structure which must be disrupted each time the double helix is accessed during replication. ‘Epigen…
THE FRANCIS CRICK INSTITUTE LIMITED
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