CORDIS Project
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This project investigates how DNA sequence influences its mechanical properties and chromosomal organization. By using advanced modeling techniques, it aims to clarify the relationship between DNA structure and gene regulation, potentially impacting our understanding of genetic diseases.
Beyond its role in encoding the primary structure of proteins, the sequence of DNA also determines its mechanical properties such as shape and flexibility.
This sequence-specific mechanical code significantly influences interactions between the cellular machinery and the genome, affecting critical processes such as gene regulation and chromatin organization.
However, the extent to which this MECHanical GENome drives biological function remains largely unexplored. MECHGEN seeks to bridge this gap…
THE UNIVERSITY OF EDINBURGH
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