CORDIS Project
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This research focuses on the role of spectrin, a protein involved in maintaining cell shape, in various cell types. It aims to explore how spectrin contributes to cell dynamics, mechanosensation, and adaptation through advanced imaging and mechanical testing techniques.
Multicellular organisms have evolved complex mechanisms to sense and adapt to the surrounding environment by dynamically controlling cell shape and exert forces.
While the most studied mechanisms are the Actin and Microtubule networks, there is poor understanding of a third system called Intermediate Filaments.
In this context, a particularly overlooked mechano-sensing protein is spectrin, a resilient structural platform firstly described to maintain cell shape in erythrocytes and recently propo…
IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS
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