CORDIS Project
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This project explores how the mechanical properties of three-dimensional extracellular matrices influence cell behavior, particularly in cancer. By developing hydrogels that mimic breast tissue, it aims to understand the role of viscoelasticity in cell migration and epithelial to mesenchymal transition.
Extracellular matrix (ECM) mechanical properties have emerged as key promoters of processes such as cell migration and epithelial to mesenchymal transition (EMT) in cancer.
Despite recent advances in the understanding of cellular ECM sensing machinery, mimicking tissue microenvironments in vitro is highly challenging, and most research has been focused on two dimensional (2D) elastic substrates.
However, ECMs are not merely 2D elastic substrates, but rather viscoelastic three dimensional (3D) ma…
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
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United States, Cambridge
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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