CORDIS Project
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This project addresses the challenge of mechanoresistance in pancreatic cancer, which reduces the effectiveness of chemotherapy. By identifying mechanisms that promote this resistance, it aims to develop new therapeutic strategies to enhance treatment outcomes.
Cancer progression is closely associated with generation of mechanical stresses that cause the compression of tumor vessels, drastically reducing delivery of drugs.
My co-workers and I found that host cells and extracellular matrix in tumors generate these stresses.
Furthermore, we identified the anti-hypertensive losartan to alleviate intratumoral stresses and decompress vessels, allowing drugs to enter the tumor.
My colleagues tested losartan in pancreatic cancer patients and found improved re…
UNIVERSITY OF CYPRUS
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