CORDIS Project
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This project investigates how mechanical forces influence the enzymatic processes of proteolysis at the single molecule level. By employing advanced techniques like force-clamp spectroscopy, it aims to uncover the molecular mechanisms that dictate enzyme-substrate interactions under varying mechanical conditions.
Single-molecule enzymology offers new possibilities to dissect catalytic reactions that were previously unapproachable using biochemistry techniques conducted in the bulk.
In particular, recent discoveries conducted at the single molecule level, such as the unanticipated force-mediated protein degradation pathway in the proteasome, highlight the close relation between mechanical forces and proteolysis in vivo.
While much has been discovered about protein enzymology in the recent decades, the que…
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