CORDIS Project
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This project investigates how mechanical forces influence cell adhesion at junctions in developing fruit fly embryos. By studying integrin-based connections to the extracellular matrix, the research aims to understand tissue integrity and its implications for diseases like muscular dystrophies.
Cells in our bodies constantly experience mechanical forces from their microenvironment.
When cells sense a critical threshold of elevated tension, they hold tight together and allow tissues to function healthily as a group.
In certain diseases, however, our cells lose their mechanosensing and adhesive properties and, as a result they get dissociated, as in the case of muscular dystrophies.
Integrin-based adhesions to the extracellular matrix (ECM) are emerging as key networks of mechanotransmis…
BIOMEDICAL RESEARCH FOUNDATION, ACADEMY OF ATHENS
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON
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