CORDIS Project
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This project investigates the role of the extracellular matrix in aging by analyzing how changes in cell-ECM communication affect mechanotransduction in skin cells. By utilizing advanced techniques like single-cell RNA sequencing and spatial transcriptomics, it aims to identify ECM components that could rejuvenate aged…
A recent work published by the host laboratory had redefined aging as a mechano-disease.
Transcriptional co-factors YAP/TAZ, masters of mechanotransduction, were critical in stromal cells to prevent aging.
Importantly, restoring cell-ECM communication and YAP/TAZ level was sufficient to ""rejuvenate"" old cells.
Consequently, we hypothesize that the culprit of aging should be searched in ECM changes that drive the loss of mechanotransduction in stromal cells.
Using single cell RNA-sequencing…
UNIVERSITA DEGLI STUDI DI PADOVA
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