CORDIS Project
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This project investigates how cells manage DNA damage during replication, focusing on the sliding clamp protein PCNA. It aims to understand the mechanisms of DNA damage bypass and its regulation, utilizing advanced technologies to analyze chromatin dynamics and the coordination of cellular processes involved in genome…
During its duplication, DNA, the carrier of our genetic information, is particularly vulnerable to decay, and the capacity of cells to deal with replication stress has been recognised as a major factor protecting us from genome instability and cancer. A major pathway that allows cells to overcome or bypass DNA lesions during replication is activated by posttranslational modifications of the sliding clamp protein PCNA.
Whereas monoubiquitylation of PCNA allows mutagenic translesion synthesis by d…
INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH
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