CORDIS Project
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This project investigates the mechanisms of protein degradation through the ubiquitin-proteasome system, focusing on the role of ubiquitin-conjugating enzymes and ligases. It aims to clarify how polyubiquitin chains are formed and their significance in marking misfolded proteins for degradation, using both cellular and…
Cell function and viability are dependent upon proper protein folding.
To avoid abnormal and toxic deposition of proteins, the cells recruit the ubiquitin-proteasome system, by which ubiquitin-conjugating enzymes (E2s) and ubiquitin ligases (E3s) work together to assemble poly-ubiquitin chains on misfolded or misassembled proteins, to be marked for degradation by the 26S proteasome.
With the maturation of the ubiquitin research field, a number of general principles have emerged about the enzyma…
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