CORDIS Project
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This project investigates the mechanisms of mRNA transport and localization in neurons, focusing on how RNA-binding proteins and motor proteins interact to regulate gene expression. By using advanced biochemical techniques, it aims to uncover the essential factors involved in dendritic mRNA transport and translational…
Active mRNA transport and localisation are crucial for spatiotemporal control of gene expression.
In neurons, dendritic mRNA transport and local translational control are required for synaptic plasticity and memory formation.
Misregulation has been linked to severe diseases. RNA-binding proteins (RBPs), kinesin motor proteins, mRNAs and noncoding RNAs (ncRNAs) are involved in dendritic mRNA transport and translational regulation.
Still it is not known which essential set of factors is required t…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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