CORDIS Project
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This project investigates how the intracellular bacterium Listeria monocytogenes interacts with immune cells, specifically macrophages, to manipulate host immune responses. It aims to identify bacterial factors that activate innate immune pathways, focusing on multi-drug resistance transporters and their role in trigge…
A central problem in microbial pathogenesis is how cells of the immune system recognize and respond to pathogens, and conversely, how pathogens avoid and/or manipulate the host response.
In order to approach this problem, we have chosen to focus on the interaction between the intracellular bacterial pathogen, Listeria monocytogenes and the immune cells, macrophages.
Macrophages, express surface and cytosolic innate immune receptors that recognize conserved molecules of microbial origin, leading…
TEL AVIV UNIVERSITY
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