CORDIS Project
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The project aims to elucidate the mechanisms of DNA replication in human cells by reconstituting the replication machinery in vitro. It will explore how the helicase is activated and regulated, providing insights into the fundamental processes of cell division and potential therapeutic targets for diseases.
Eukaryotic DNA replication is mediated by a complex machinery consisting of several dozen proteins that ensures precise duplication of chromosomes in S phase of the cell cycle.
The Diffley laboratory recently reconstituted the core Saccharomyces cerevisiae replication machinery in vitro from 19 replication factors containing about 50 individual protein subunits.
This system allowed to study mechanisms of yeast MCM loading onto DNA and of yeast CMG replicative helicase activation.
In human cells…
THE FRANCIS CRICK INSTITUTE LIMITED
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