CORDIS Project
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The project investigates how blood cells, particularly hematopoietic stem cells, develop from uncommitted embryonic cells using zebrafish models. By identifying genetic markers and transcription factors, the research aims to uncover mechanisms that can guide cell fate towards blood cell formation for therapeutic applic…
How blood cells and ultimately hematopoietic stem cells (HSCs) arise from uncommitted cells during development is only vaguely understood.
Especially the initial formation of the first blood precursors in lateral mesoderm has been difficult to dissect.
Investigating these early mechanisms of blood cell fate determination with genetic model systems provides a vital starting point for therapeutic drug discovery and the targeted manipulation of iPS cells to treat hematologic diseases.
The goal of t…
University of Zurich
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