CORDIS Project
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This project aims to uncover the mechanisms behind the assembly and maintenance of centromeric chromatin in fission yeast. By identifying factors that influence centromere integrity, it seeks to enhance understanding of chromosome segregation during cell division.
Centromeres are vital structures on eukaryotic chromosomes that are essential for proper chromosome segregation during cell division.
Centromeric DNA is bound by a centromere-specific variant of histone H3 known as CENP-A that replaces canonical H3 in centromeric chromatin, thus specifying centromere identity.
The regulation of CENP-A chromatin assembly, however, remains poorly understood.
Here, I propose experiments directed towards understanding how CENP-A chromatin is established and faithfull…
THE UNIVERSITY OF EDINBURGH
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