CORDIS Project
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This project investigates how certain mRNAs, particularly those involved in cancer, utilize an internal ribosome entry site for translation. By studying the role of the poly(A) tail and regulatory factors, the research aims to enhance understanding of translation control mechanisms in tumorigenesis.
The central importance of translation control in cancer is just beginning to be fully appreciated.
Translation normally initiates with the recruitment of the initiation factors to the 5’ cap of the mRNA for ribosome binding.
Curiously, some normally capped cellular messages, which are involved in cell-cycle control, growth and apoptosis, rely alternatively on an internal ribosome entry site (IRES) at their 5’ end and the 3’ poly(A) tail to support translation.
The advantage conferred by the IRES…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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