CORDIS Project
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This project investigates the dynamics of reverse transcriptase, an enzyme critical for HIV replication. By developing single molecule assays, it aims to uncover the mechanisms of enzyme interactions with nucleic acids and identify potential new strategies for HIV treatment.
The oncogenic human immunodeficiency virus (HIV) currently infects an estimated 33 million individuals and has claimed more than 25 million lives.
The primary treatment of HIV consists of a cocktail of several classes of antiretroviral drugs targeting various components of the HIV virus.
The most utilized target of antiretroviral drugs is reverse transcriptase (RT), an enzyme that transforms the viral genome from ssRNA to dsDNA.
Unfortunately, significant gaps remain in our understanding of how…
TECHNISCHE UNIVERSITEIT DELFT
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