CORDIS Project
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This project explores the mechanics of cell compaction during early mouse embryonic development. By using advanced biophysical methods and microscopy, the research aims to characterize the mechanical properties and molecular interactions that drive this critical morphogenetic event.
Compaction is the earliest morphogenetic event in mouse embryonic development during which blastomeres increase the size of their cell-cell interfaces.
This permits the establishment of apico-basal polarity and thereby the 1st fate specification of the blastomeres: trophectoderm derives from blastomeres with a large apical membrane at the cell-medium interface; whereas blastomeres composing the inner cell mass descend from cells with comparably larger basal cell-cell interfaces.
Essential molecu…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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