CORDIS Project
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This project investigates how the mechanical properties of DNA influence nucleosome positioning, using advanced imaging techniques. It aims to uncover the biophysical mechanisms that regulate gene expression and their implications for cancer development.
Recent breakthroughs found that mechanical features of gene promoters influence nucleosome positioning through ATP-dependent chromatin remodeling enzymes.
This finding challenges classical models of DNA-sequence-dependent histone recruitment.
While mechanisms for the translation of DNA’s physical parameters to nucleosome positions are debated, their experimental validation is still pending.
MebaGINO aims to address this fundamental gap in knowledge.
Taking advantage of recent advances in time-re…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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