CORDIS Project
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This project investigates how the genome influences the development of the fruit fly, Drosophila melanogaster, by using advanced techniques to measure gene expression across its entire growth. It aims to create a detailed 4D model of development that links cellular states and differentiation processes.
How the genome regulates the differentiation trajectories that instruct a single fertilised egg to develop into an adult organism is a longstanding question in biology.
Here, high-throughput spatial transcriptomics will be leveraged to virtually measure all cellular states of the Drosophila melanogaster.
The entire ten-day development of the fruit fly will be sampled with a four-hour interval, where the spatial gene expression of 1,600 genes will be measured in a serially sectioned fly at single…
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