CORDIS Project
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This research focuses on the mitochondrial antiviral signaling protein and its interaction with a novel RNA helicase during antiviral responses to RNA viruses like HIV-1. By characterizing the molecular mechanisms involved, it aims to identify new therapeutic targets for enhancing antiviral immunity.
The mitochondrial antiviral signalling (MAVS) adaptor protein is a central signalling hub for host cells to mount an antiviral response following RNA virus infections, which is initiated by the cytosolic receptors that trigger the type-I interferon (INFs) path through the MAVS.
Recently, it has been shown that the RNA helicase DDX3 is a novel atypical member of the viral cytosolic receptor pool and it is required to activate the MAVS during the antiviral response.
In fact, DDX3 is crucial in the…
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
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