CORDIS Project
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This project investigates the role of microglia, the brain's immune cells, in regulating energy and glucose metabolism through their interaction with hypothalamic neurons. It focuses on the gene Trem2, which influences microglial states and their impact on brain development and function.
Microglia represent the main brain residential immune cells.
In the last years evidence emerged that, besides representing the first line of defense against pathogenic insults, microglia are also centrally involved in physiological functions essential for correct CNS development and function.
Microglia, in a spatially and temporally controlled manner, influence neuronal apoptosis, neurogenesis and myelin formation and manage synapse homeostasis, including removing supernumerary synapses during…
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