CORDIS Project
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This project explores the formation of signaling microdomains in cell membranes, focusing on how protein-lipid clusters contribute to cell functions such as polarity and communication. Mathematical models will be employed to understand the dynamics of these clusters.
Assembly of transient and stable signaling platforms in the plasma membrane of cells has been implicated in functions as varied as death and survival, polarity, differentiation, migration, cell-cell communication, virus entry, exocytosis, endocytosis.
Naturally, the assembly of signaling microdomains requires the use of most complex molecular mechanisms capable of transducing intrinsic or extrinsic information into the actual making of the domain.
Consensus exist that the lateral diffusion and h…
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