CORDIS Project
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This research focuses on the regulation of mRNA translation during the transition from oocyte to embryo, exploring the role of surrounding somatic cells. It aims to identify mechanisms that could impact embryo development, particularly in relation to reproductive aging.
The final phase of oocyte differentiation, fertilization and early embryo development occur in absence of transcription, thus cell cycle progression and genome reprogramming rely on translation of stored mRNAs, until the activation of embryo genome.
Objective of the present study is to analyze the pathways that regulate translation during oocyte-to-embryo transition.
We propose the follicular cells to play a role in this process.
Though it is known that intercellular bi-directional communication…
UNIVERSITA DEGLI STUDI DI MILANO
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