CORDIS Project
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This project focuses on understanding the conformational dynamics of secondary membrane transporters using a novel mass spectrometry technique. By studying the glutamate transporter and others, it aims to link structural changes to their functional roles in transporting molecules across membranes.
Secondary membrane transporters are found across the biological kingdom.
The structural dynamics of their actions are elusive, as our understanding relies on few X-ray structures.
Comparisons of the available structures show that large re-arrangements take place between two domains during transport, with what is generally described as a “rocking-bundle model”.
However, dynamic motion between the transport domains remains largely inaccessible to most experimental analysis methods.
Here we propose…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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