CORDIS Project
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This project explores the role of mono-ADP-ribosylation in cellular functions using advanced microscopy techniques. By investigating its localization and interactions, it aims to reveal new insights into this modification's therapeutic potential and biological significance.
ADP-ribosylation (ADPr) is a key post-translational modification catalyzed by the ADP-ribosyltransferase (ART) superfamily, including poly-ADP-ribose polymerases (PARPs), which, despite their name, can transfer either a single (mono-ADPr) or multiple (poly-ADPr;
PAR) units of ADP-ribose to their targets.
This process occurs in response to various biological and pathological stimuli, regulating numerous cellular functions.
For many years, research in the ADPr field focused primarily on poly-ADPr…
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