CORDIS Project
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This project focuses on the regulation of gene expression through mRNA-binding proteins, particularly poly(A)-binding proteins. It aims to uncover how post-translational modifications influence their interactions and functions, which is crucial for understanding various disorders linked to gene dysregulation.
Post-transcriptional control of human gene expression is conferred by >1000 mRNA-binding proteins (RNA-BPs), which determine the utilisation and fate of mRNAs, with the aetiology of a wide-range of disorders (e.g. neurological, inflammatory, and neoplastic) being due to their dysregulation.
Multifunctionality is a feature of RNA-BPs and understanding how this is coordinated and regulated is pivotal to delineating the molecular circuitry of post-transcriptional gene regulatory networks, to unders…
THE UNIVERSITY OF EDINBURGH
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