CORDIS Project
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This project explores the receptor interactions of influenza viruses with host cells, focusing on the binding mechanisms of hemagglutinin proteins. It aims to develop a new method for analyzing glycan array data to enhance understanding of receptor specificity.
Influenza viruses belong to the family of Orthomyxoviridae and cause acute viral disease of the respiratory tract.
Influenza virus enters the cell via receptor-mediated endocytosis and subsequent fusion with the cell membrane.
Influenza virus hemagglutinin (HA) is responsible for these binding and fusion events. HA binds to sialic acid (SA) receptors on the host cell-surface.
These SA receptors vary in structures and are species and tissue specific.
The preference for a certain SA receptor is in…
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