CORDIS Project
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This project investigates how certain inhibitors can destabilize protein kinases, which may enhance their therapeutic effects. By developing innovative assays and utilizing high-throughput screening, the research aims to systematically map these destabilizing interactions and explore their potential for designing targe…
Inhibitor-induced target destabilisation has been reported sporadically in recent years.
Importantly, despite never actually having been put in place on purpose – or by design – these effects often play a significant role towards their therapeutic effect.
To date, no systematic approach to map or quantify these serendipitous destabilising events has, however, been performed, representing a huge underexplored space with large translational potential. I here propose to study ligand-induced destabi…
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