CORDIS Project
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This project explores a new form of cellular senescence, termed Pten loss Induced Cellular Senescence (PICS), to target quiescent cancer stem cells in prostate cancer. By manipulating Pten signaling, the research aims to develop therapies that induce irreversible growth arrest in these cells, offering a novel approach…
This proposal aims to harness a novel type of senescence that we have identified in response to acute Pten inactivation, and which we believe offers a radical therapeutic approach to target the quiescent cancer stem cell in vivo.
In characterizing Pten loss Induced Cellular Senescence, which we have named PICS for short, we have discovered that PICS is distinct from other forms of cellular senescence including oncogene-induced senescence (OIS) and replicative senescence.
These distinct differenc…
Ente Ospedaliero Cantonale
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