CORDIS Project
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This project investigates the role of macrophage-stimulating protein in activating a key energy regulator, AMP-activated protein kinase, to treat non-alcoholic steatohepatitis, a liver disease linked to metabolic syndrome. The research aims to explore the molecular mechanisms and potential therapeutic applications of t…
BACKGROUNDNon–alcoholic steatohepatitis (NASH) is the hepatic event of the metabolic syndrome and is characterized by steatosis and inflammation.
Although our understanding of the disease mechanisms has progressed, the therapy options for treatment of NASH remain poor. AMP-activated protein kinase (AMPK) is an important integrator of signals managing energy balance and acts as a protective response to energy stress during metabolic deregulations.
Pharmacologic AMPK activation is a well-establish…
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