CORDIS Project
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This project investigates the role of Hedgehog signaling in the development of mammary gland stem cells and its implications for breast cancer. It explores how specific genetic changes and signaling pathways contribute to tumor formation and potential therapeutic interventions.
Only a subset of tumour cells is capable of giving rise to new tumours.
These so called “tumour stem-cells” are functionally similar to adult stem cells and have been identified in tumours of several tissues.
Whether transformation of adult stem cells into tumour stem cells is the event leading to the disease is not clear.
Alternatively, tumours could arise from the population of committed progenitors, which have de novo acquired self-renewal properties.
The aim of the proposed project is to inv…
KAROLINSKA INSTITUTET
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