CORDIS Project
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MAMELI explores how environmental factors influence genetic changes associated with health. By studying repetitive elements in DNA, the project aims to understand how these elements adapt to environmental stimuli and develop a predictive algorithm for assessing health risks based on genetic methylation patterns.
The concept of exposome encompasses all human disease determinants encountered during the life course.
The exposome induces epigenetic modifications (e.g., DNA methylation).
Several studies have investigated how repetitive elements (REs) can be switched on in response to environmental stimuli, but have started from the assumption that altered RE methylation is always detrimental to the health of the affected individual. MAMELI proposes an alternative hypothesis that some REs are plastic entities…
UNIVERSITA DEGLI STUDI DI MILANO
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