CORDIS Project
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This study investigates the role of specific proteins in human neural stem and progenitor cells to understand their prolonged proliferation compared to other mammals. By examining these mechanisms, the research aims to shed light on brain development and neurodevelopmental disorders.
The evolutionary expansion of the neocortex in the primate lineage, and particularly in humans, underpins our higher cognitive abilities.
Neural stem and progenitor cells (NPCs) show increased duration of proliferative phases in humans when compared to other mammals and particularly mice.
However, the mechanisms responsible for these evolutionary differences in progenitor properties are poorly understood.
In this study, I aim to explore the function of the ASCL1 and MYCN proteins in human NPCs.…
THE FRANCIS CRICK INSTITUTE LIMITED
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