CORDIS Project
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This project investigates the molecular mechanisms behind gene expression switching in the malaria-causing parasite Plasmodium falciparum. By developing a tool for conditional gene expression, the research aims to uncover how the parasite adapts to its environment and evades the immune system.
The malaria-causing parasite Plasmodium falciparum has evolved a strategy of clonally variant gene expression to control essential biological processes like antigenic variation and sexual commitment during its persistent blood-stage infection of the human host.
Heritable epigenetic silencing of the underlying specialized gene families ensures the limited expression of only a subset of these genes at any time.
Switching the expression of individual clonally variant genes enables the parasite to r…
EBERHARD KARLS UNIVERSITAET TUEBINGEN
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Germany, Hamburg
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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