CORDIS Project
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This project aims to understand the mechanisms behind the egress of malaria parasites from red blood cells, focusing on the roles of specific proteins. By employing genetic techniques, it seeks to identify potential drug targets that could block the parasite's ability to exit host cells and thus halt disease progressio…
The malaria parasite Plasmodium falciparum, which causes ~600,000 deaths annually, propagates within host erythrocytes.
Roughly synchronous egress of blood stage parasites in vivo causes the periodic fevers associated with malaria and is essential for parasite replication.
Blocking parasite egress can stop disease progression, so understanding its mechanism is key to identifying new drug targets.
Egress of malaria parasites from host erythrocytes involves the rupture of two membranes- the parasi…
THE FRANCIS CRICK INSTITUTE LIMITED
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