CORDIS Project
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This project explores the mechanisms of DNA methylation maintenance within chromatin, focusing on how nucleosomes influence this process. By identifying new factors and developing a mathematical model, the research aims to clarify the relationship between DNA methylation and nucleosome dynamics.
Cytosine methylation is a chemical modification that is precisely copied when DNA is replicated.
Because methylation can regulate gene expression, accurate reproduction of DNA methylation patterns is essential for plant and animal development and for human health.
The enzymes that maintain DNA methylation have to work within chromatin, and particularly to contend with nucleosomes – tight complexes of DNA and histone proteins.
How methylation of nucleosomal DNA is maintained remains unknown, and…
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
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United Kingdom, Norwich
Type: Research institute
Activity type: Research Organisations
SME: No
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