CORDIS Project
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This project develops a novel imaging technique combining Magnetic Resonance Imaging and light microscopy to visualize specific cells in intact tissues. By using engineered contrast agents, it aims to enhance imaging resolution and enable the study of cellular interactions in the brain, particularly in neurodegenerativ…
Imaging defined cells, over extended time, depends on signal strength, stability, accessibility and specificity.
Whereas light-microscopy (LM) can provide these, it does not allow imaging of entire intact tissues; imaging-depths and area-size are restricted, and not easily obtained through skin and bone.
Magnetic Resonance Imaging (MRI) outperforms LM in these instances; providing images of large-fields-of-view (i.e., mesoscale), at any depth, easily across bone.
Nevertheless, MRI suffers from l…
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