CORDIS Project
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This project focuses on creating human 3D neuromuscular organoids to better understand neuromuscular disorders. By applying mechanical and brain-like stimuli, the research aims to enhance the maturation of these organoids for studying diseases such as spinal and bulbar muscular atrophy.
*Neuromuscular disorders, whose incidence and prevalence have increased over time have currently no cure, and understanding their pathological mechanisms remains challenging due to the lack of reliable human in vitro models. A groundbreaking approach involves human 3D trunk neuromuscular organoids (NMOs) that replicate the cellular diversity and the functional dynamics of the neuromuscular system.
However, the absence of in vivo-like external stimulations leads to reduced contractions and preven…
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
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