CORDIS Project
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This project investigates how chronic bacterial infections, particularly Helicobacter pylori, contribute to cancer development through mutations in epithelial tissues. By studying organoids, the research aims to uncover how these mutations serve as a defense mechanism against infections.
The epithelial surfaces are frequently affected by harsh encounters, thus it is not surprising that most cancers originate here.
Several chronic bacterial infections have been implicated in human cancers, with Helicobacter pylori (Hp) representing the paradigm of a cancer-inducing bacterium.
The gastric pathology of infection tends to progress from mild symptoms, via active gastritis, atrophy, gastric intestinal metaplasia (GIM) and dysplasia towards gastric adenocarcinoma.
Intriguingly, GIM is…
CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
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