CORDIS Project
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This project investigates how changes in gut microbiota affect cancer resistance to immunotherapy. It focuses on the mechanisms regulating immune cell behavior and aims to identify how these interactions influence treatment outcomes, potentially improving cancer therapies.
Resistance of cancers to immune checkpoint blockade (ICB) can result from a deviated taxonomic composition of the intestinal microbiota. A surge in the Enterocloster genus, for instance following discontinuation of antibiotics or chronic inflammation caused by tumors, induces the downregulation of MAdCAM-1 in the ileal lamina propria and mesenteric lymph nodes through perturbations of biliary salts.
In turn, the ileal MAdCAM-1 loss induces the exodus of immunosuppressive T lymphocytes expressing…
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