CORDIS Project
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This project investigates the genetic factors contributing to age-related macular degeneration (AMD), focusing on rare genetic variants. The goal is to enhance understanding of the disease mechanisms and improve risk assessment and treatment options for affected individuals.
Age-related macular degeneration (AMD) is the most common cause of irreversible blindness in the Western world. AMD has a strong genetic component, and it has been estimated that 50% of the heritability of AMD is explained by common variants in the complement system.
Currently the first genetic tests based on a small number of common variants are being marketed, and new treatment modalities are being developed targeted to inhibit complement activation in AMD.
However, genetic tests are not likel…
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