CORDIS Project
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This project investigates how liver macrophages respond to microbial threats, focusing on the distinct roles of resident and recruited macrophages. By utilizing advanced mouse models and human liver organoids, the research aims to clarify the activation mechanisms of these immune cells, potentially leading to improved…
Despite playing essential roles in immunity against microbes, the cellular and molecular mechanisms underpinning macrophage (mac) responses to microbial insults remain incompletely understood.
In the liver, Kupffer cells (KCs) the tissue-resident macs, reside in the bloodstream of the liver sinusoids and are thus ideally positioned to recognize and phagocytize microbes and microbe-derived components critically contributing to systemic immune surveillance.
In addition, KCs are thought to play cen…
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