CORDIS Project
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This project investigates how cells in human tissues respond to mechanical stress and adapt to changing conditions. By studying matrix adhesion proteins in engineered 3D tissue models, it aims to uncover the mechanisms behind tissue remodeling in both healthy and diseased states.
Tissues in the human body are exposed to cyclic loading and have the capacity to adapt, to meet new loading demands.
Cells facilitate such adaptation by responding to mechanical triggers, which depends on the balance between endogenous tension (cellular forces) and exogenous tension (matrix stiffness and resistance to stretch).
This is regulated by matrix adhesions: the cellular force sensors.
In healthy tissue, cells can positively contribute to tissue functioning by synthesizing additional mat…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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