CORDIS Project
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The MACROVALVE project investigates the role of macrophages in the degeneration of bioprosthetic heart valve leaflets, focusing on differences between male and female responses. By employing advanced techniques like multi-omics and electron microscopy, the project aims to develop new therapies to enhance the longevity…
Heart valve disease is predicted to be the next cardiac epidemic.
Valve prostheses used to treat this disease are comprised of biological tissue.
However, these bioprosthetic leaflets degrade, limiting their long-term efficacy.
Macrophages have been found within explanted leaflets and are key determinants of biocompatible outcome.
However, their role in bioprosthetic leaflet remodelling is poorly understood.
Males and females for unknown reasons are also predisposed to calcific and fibrotic leaf…
UNIVERSITY OF GALWAY
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United States, Boston
Type: Research institute
Activity type: Research Organisations
SME: No
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